Fumihiko Urano, MD, PhD, the Samuel E. Schechter Professor of Medicine, and Emil Unanue, MD, the Paul and Ellen Lacy Professor of Pathology and Immunology received a two-year, $500,000 grant from the Juvenile Diabetes Research Foundation for research titled “Endoplasmic Reticulum Stress and Immunological Autoreactivity.”
Dr. Urano’s research group discovered that Wolfram syndrome, a genetic form of diabetes, is caused by the interaction between a particular type of cell stress and genetic factors. In their collaboration, Drs. Urano and Unanue have found that the same type of cell stress is involved in type 1 diabetes and autoimmunity. Through the doctors’ collaboration, they will elucidate a common biological process altered in Wolfram syndrome and type 1 diabetes. Their study can lead to a breakthrough in treatments for type 1 diabetes.