Office Location: Wohl Clinic Building, 5th Floor
660 S. Euclid Ave.
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 747-0170
Fax: (314) 747-3963
Email Address: firstname.lastname@example.org
Dr. Moynihan is originally a native of Los Angeles, California. She did her undergraduate training at the California Institute of Technology in Pasadena, with a research focus on interactions among collagen genes in C. elegans. She considers herself an honorary Midwesterner after completing her MD and residency in internal medicine at Washington University in St. Louis before joining the Endocrine and Metabolism fellowship program.
Type 2 diabetes continues to be an increasing health problem in America and across the world. Particularly because it goes hand in hand with high blood pressure and cardiovascular disease, it can become a life-threatening problem. Although we know inflammation is a part of this process, we don’t fully understand how it occurs, or how it could best be treated. Diabetes, high blood pressure, heart disease, and many signs of inflammation are associated with low vitamin D levels. Higher vitamin D levels suppressed signs of inflammation and insulin resistance in many studies, suggesting that it may be a potential therapy for patients with diabetes. We hope to answer two questions: how does low vitamin D cause inflammation, and can you improve health of patients with diabetes by treating with vitamin D?
Dr. Moynihan is investigating why macrophages, which are an important part of the immune system and inflammation, start to use fat instead of sugar when deprived of vitamin D. In addition, she is part of the clinical trials team which is investigating whether supplementing vitamin D improves blood pressure and signs of cardiovascular disease. She plans to link these two projects by directly examining the macrophages from diabetic patients enrolled in the clinical trials.