Office Location: 815J SW Tower
660 S. Euclid Ave
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 747-6473
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Cynthia Cipolla was born and raised in Akron, OH. She graduated summa cum laude with a bachelor of science from Ohio University in 2009, where she majored in forensic chemistry and minored in biological sciences. She then entered graduate school at the University of Michigan, where she earned her Ph. D. in analytical chemistry in 2015 under the guidance of Dr. Robert Kennedy. Her Ph. D. work focused on developing analytical methods that could be used to evaluate function in pancreatic islets of Langerhans prior to clinical islet transplantation. She joined Irfan Lodhi’s laboratory as a postdoctoral research scholar in 2015 to study the function of peroxisomal lipid metabolism in islets.
Obesity can lead to insulin resistance, pancreatic beta-cell compensation, and eventual beta-cell failure, culminating in type 2 diabetes. Alterations in lipid metabolism have been implicated in this progression. Lipids are metabolized intracellularly in both mitochondria and peroxisomes, although less is known functionally about peroxisomal lipid metabolism. My research involves the use of beta-cell-specific knockout mouse models of peroxisomal enzymes in the context of diet-induced obesity to study the role of peroxisomal lipid metabolism dysfunction in the development of type 2 diabetes.