Postdoctoral Research Fellow
Office Location: 815D SW Tower
Mailing Address: 660 S. Euclid Ave.
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 362-3802
Email Address: email@example.com
Daniel grew up in Asheville, NC. He graduated summa cum laude with a bachelor of science in 2006 from Emory & Henry College, where he majored in Biology with Chemistry minor. He attended graduate school at Wake Forest University School of Medicine and earned a Ph.D. in Molecular Pathology in 2015 under the guidance of Dr. J Mark Brown. While in graduate school, Daniel moved with his mentor to the Cleveland Clinic Foundation. His Ph.D. work focused on hepatic steatosis induced by the hepatitis C virus core protein. In 2017, he joined the lab of Dr. Charles Harris to study the role of glucocorticoid receptor in metabolic syndrome.
The glucocorticoid receptor (GR) is activated by glucocorticoids, which are stress hormones that are found at high levels in key insulin-responsive tissues such as liver and adipose. Additionally, synthetic glucocorticoids are commonly used therapeutically for inflammatory diseases such as asthma, inflammatory bowel disease and arthritis. Unfortunately, the use of synthetic glucocorticoids is hampered by adverse side effects including weight gain and insulin resistance. Recent groups have shown that GR can be post-translationally modified yet the roles of these modifications in vivo are unknown. Due to the importance of glucocorticoids and GR in inflammation and metabolism my research focuses on the role of GR post-translational modifications in hepatic and adipocyte lipid metabolism in vivo, using genetically modified mice.