Office Location: 8808 Wohl Hospital
660 S. Euclid Ave
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 362-8671
Email Address: firstname.lastname@example.org
Jana Mahadevan performed her pre-doctoral training under Dr. Rama Rajaram at Biochemistry Laboratory, Central Leather research Institute, India. She investigated the different modes of cell death in human peripheral blood lymphocytes by a Type-2 diabetic nutritional supplement Chromium (III) picolinate and identified important signal transduction pathways that lead to cell death. She pursued her postdoctoral training in Dr. Paul Robertson’s laboratory at Pacific Northwest Diabetes Research Institute in 2010, where she studied islet biology. She investigated the effects of antioxidants in a rodent model of Type 2 Diabetes and the possible mechanism for oxidative stress induced beta cell dysfunction using both in vitro and in vivo studies in order to develop new therapeutic strategies. Following her first postdoctoral experience, currently she expanded her research in the laboratory of Dr. Fumihiko Urano as a Postdocotoral Research Associate where she is elucidating the role of endoplasmic reticulum (ER) stress and pancreatic beta cell death.
My long-term research interest involves the development of comprehensive understanding of key signaling molecules and how alterations in gene expression contribute to human diseases particularly ER stress disease and diabetes. Endoplasmic recticulum (ER) is an important site of protein folding, calcium storage, redox regulation and intracellular signaling. The pancreatic beta cells are equipped with highly developed ER to fulfill the requirement of secreting a large amount of insulin. Thus increase in ER stress associated with the induction of unfolded protein response (UPR) and ER stress, which further exacerbates beta cell death. Understanding the role of ER stress in the loss of beta cell mass and dissecting the mechanisms underlying ER stress would be important for developing therapeutic approaches aimed at prevention and intervention of diabetes.