Office Location: 836 SW Tower
660 S. Euclid Ave.
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 747-1168
Fax: (314) 747-3963
E-mail Address: firstname.lastname@example.org
Jing grew in China and moved to the US in 1991. She attended Stanford University as undergraduate and completed M.D. Ph.D. training at University of Pennsylvania, with research on circadian rhythm and metabolic disease. She went on to do a fast-track residency and clinical endocrinology fellowship, then moved to St. Louis and finished her research fellowship at Washington University. She is now Instructor in Medicine in the Endocrine Division and focusing her work on type 1 diabetes. Jing and her husband Michael have three young daughters and enjoy living in St. Louis.
Type 1 diabetes is a fascinating autoimmune disease that affects millions worldwide, many of whom are children. Dr. Hughes studies how beta cells become targeted by immune cells, specifically through antigen transfer events that occur in the islet. We believe that understanding early events of antigen recognition will lead to discovery of drugs to stop the autoimmune process, thereby halting or even preventing the development of type 1 diabetes.
Dr. Hughes has had extensive research experience as a beta cell biologist. While at Yale, she pioneered a high-throughput imaging technique to study beta cell death in autoimmune diabetes in mice. Here at Washington University, Dr. Hughes is working with colleagues in the Unanue and Piston laboratories to study beta cell-macrophage interactions and how this leads to immune activation. Dr. Hughes is actively involved in patient care and teaching, and has aided in a number of clinical trials that study the role of new immune-modulator drugs on type 1 diabetes.