Office Location: 829K SW Tower
660 S. Euclid Ave
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 747-8282
Fax: (314) 362-7641
Email Address: firstname.lastname@example.org
Larry Spears was born in Carbondale, IL. He graduated cum laude with a bachelor of science in 2007 from Fontbonne University, where he majored in biology and minored in chemistry. In 2012, he received his Ph.D. from Saint Louis University (SLU) in biology. While at SLU, he studied the pathways in which exercise and insulin increase glucose transport into muscle, under the direction of Dr. Jonathan Fisher. In 2012, he joined Dr. Clay Semenkovich’s laboratory as a postdoctoral research scholar to study lipid metabolism.
Endothelial dysfunction is one of the hallmarks in patients with type 1 and type 2 diabetes. PPARy plays an important role in normal endothelial function. For example, endothelial-specific PPARy knockout mice have impaired vasoreactivity. Phospholipids have been shown to be endogenous ligands of PPARy in adipocytes. I study the role that endogenous phospholipids play in endothelial cells, and their effect of PPARy.