Study Title: Metabolic Effects of Hydroxychloroquine
Purpose of the Study:
The purpose of this research study is to learn if hydroxychloroquine added to your current diabetes treatment will reduce blood glucose. We also hope to learn what effect, if any, the study drug may have on indicators in your blood of inflammation in your body and on LDL or “bad” cholesterol. Chronic inflammation and high LDL have been implicated in many heart, blood, and sleep disorders, including atherosclerosis, hypertension, heart failure and sleep apnea.
Eligibility: 18 to 75 years old with Type 2 Diabetes treated with Metformin Only
Exclusion: Participants must not take fish oil greater than 1000mg daily, niacin, fibrates or atypical antipsychotics; participants must not have a history of psoriasis, stroke or coronary artery disease
What Is Involved
- Duration: This study will take about 8 weeks to complete. There are up to 3 study visits. Visit 1 takes about 1 hour and Visits 2 & 3 take about 8 hours each.
- Tests/procedures: Participation includes insulin clamps (requires ability to lie on your back for 6 to 8 hours), physical exam, non- fasting blood draw, ECG, and pregnancy test if female.
- Risks: Risks will be discussed with volunteers as part of the informed consent process.
- Benefits: Benefits will be discussed with volunteers as part of the informed consent process.
- Compensation: Up to 375 dollars is provided.
Primary Outcome Measure: Change in insulin resistance over a four-week treatment period
Investigators: Clay Semenkovich, M.D.; Janet McGill, M.D.; Rachel Kilpatrick, M.D.
Stacy Hurst (314) 747-3294 firstname.lastname@example.org
Lori Buechler (314) 362-8285 email@example.com