Office Location: 849 Southwest Tower
660 S. Euclid Ave.
Campus Box 8127
St. Louis, MO 63110
Office Phone: (314) 747-0437
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I graduated from the University of Toronto, Canada with a bachelor of science in human biology and a master of Science in physiology. For my master’s thesis project with Dr. Michael Wheeler I studied the progression of type 2 diabetes in a non-obese transgenic mouse where severe insulin resistance led to the eventual failure of β-cell function and precipitating diabetes. In 2012, I joined the lab of Dr. Kelle Moley at Washington University in St. Louis. Here I learned the concept of ‘fetal programming’ whereby in utero exposure to certain conditions such as maternal health can have adverse effects on fetal health that can persist into adulthood. In Dr. Moley’s lab, I worked on the effects of a high fructose diet on metabolic health and glucose homeostasis; however my main focus was on maternal nutrition during gestation, its effects on placental-fetal outcomes and potential mechanisms leading to adverse effects.
My primary interest is in metabolism, particularly diabetes. Most of my previous work has been on type 2 diabetes in both genetic and diet induced models. Currently, I work with Dr. Maria Remedi to understand the specific role of glucotoxicity in mediating β-cell failure by utilizing a transgenic mouse model of neonatal diabetes. Our focus is on determining cellular and molecular mechanisms that lead to β-cell exhaustion and death, as well as potential preventative interventions.